Schedule for Biotechnology 540, Fall 2007:
Note: Subject to change as we finalize guest speaker dates and topics!
Getting a Drug to Market: Clinical Trials - *Michael Turik, MD, The Lilly Laboratory for Clinical Research - NOTE: Background reading!
Post Modern Science - Joe Petolino, PhD
|10/9/07||Gene Therapy - Ken Cornetta MD [web], Chair, Department of Medical and Molecular Genetics, IUSM; Director, Indiana University Gene Vector Facility|
|10/11/07||Adult and Pleuripotent Stem Cells - Merv Yoder, MD, Department of Pediatrics, IUSM; Biochemistry and Molecular Biology. Please read BEFORE Dr. Yoder's lecture!|
|10/30/07||Nutrigenomics - Starting a Nutritional Genetic Company: Manuel Sanchez-Feliz, PhD, Chief Technical Officer, Sciona; Research Advisor, Eli Lilly|
And... Gene Patents (From Dr. Marrs - NOT a patent attorney)
No Class - Thanksgiving Break
Team Projects 1-5; Link to projects
Team Projects 6-10
Team Projects 11-15
FINAL EXAM (Cumulative) Tuesday, 6-8 pm
Previously on the Right sidebar... (for historical reference)
Tip of the Day 8/30/07
IGNORE Oncourse for now, uness you have a Blunt Object you can use to BEAT IT mercilessly.
Instead, think about sailing peacefully on the Sorcerer II, circumnavigating the globe... not uploading anything to Oncourse... we'll just pause on the Warm Up assignment for now...stay tuned!
NY Times 4 Sept 07 In the Genome Race, the Sequel Is Personal Craig Venter's genome revealed...take a look!
Check out the manuscript in PLoS Biology! The Diploid Genome Sequence of an Individual Human"We have generated an independently assembled diploid human genomic DNA sequence from both chromosomes of a single individual (J. Craig Venter)..."
But Craig wasn't the first!
NY Times 31 May 2007 Genome of DNA Pioneer Is Deciphered ie: James Watson, courtesy of 454 Life Sciences!
PS. "His Master's Voice" Early ad for RCA victor (compare to the Dog Genome cover)
Investor excitement: ImClone Claims Positive Erbitux Results on Lung Cancer:A.P. NEW YORK -9/11/07
By DAMIAN J. TROISE 09.11.07, 5:49 PM ET
ImClone Systems Inc. and Bristol-Myers Squibb Co. claimed Tuesday that the drug Erbitux improved the survival rate of patients with the most common type of lung cancer in a late-stage study. Shares of ImClone climbed $6.97, or 18 percent, to $44.90 Tuesday. The stock reached a 52-week high of $47.22 earlier in the trading session.
Thanks to Joey F. from class for sending this in! ...................
NY TImes 9/7/07 Two Biotech Companies Agree to Form a Joint Venture Alnylam Pharmaceuticals and Isis Pharmaceuticals - joint venture to develop Regulus Therapeutics,an miRNA company - More on this later! [What do you think about the company name?!]
Thanks to Natalie P. from class for sending this in!
Wal-Mart is expanding its $4-a-month generic drug program, adding about seven new compounds
The company said it would also sell a month’s supply of two popular birth control medications and a fertility drug for $9 each, a move meant to lure young women shoppers to the store.
The company said it decided to offer those drugs at $9 because they would not have been profitable at $4.
News of the day:
Bush Vetoes Popular Bill on Kids' Health CareWASHINGTON Oct 3 - Well, no surprise here! This is only veto #4 of his presidency...2 on stem cells, one on S-chip...
Senate Passes Children’s Health Plan WASHINGTON, Sept. 27 — The Senate gave final approval on Thursday to a health insurance bill for 10 million children, clearing the measure for President Bush, who said he would veto it.
The 67-29 vote followed a series of speeches by Republican senators supporting the bill and urging Mr. Bush to reconsider his veto threat.
Senator Pat Roberts of Kansas, one of 18 Republicans who voted for the bill, said the White House had shown “little if any willingness to come to the negotiating table.”
3 Win Nobel in Medicine for Gene ManipulationOctober 8, 2007 7:52 a.m. ET STOCKHOLM, Sweden (AP) --'U.S. citizens Mario R. Capecchi and Oliver Smithies and Sir Martin J. Evans of Britain won the 2007 Nobel Prize in medicine on Monday for groundbreaking discoveries on gene targeting, which lets scientists inactivate or modify particular genes in mouse embryonic stem cells. That in turn lets them study how those genes affect health and disease'.
Physics of Hard Drives Wins NobelOctober 9, 2007 1:56 pm. ET STOCKHOLM, Sweden (AP) --
'France's Albert Fert and German Peter Gruenberg for giant magnetoresistance' = the magnetic hard drive that runs your iPod, MP3 player, etc!
Each prize awards $1.5 million to share between the recipients!
House Sustains President’s Veto on Child Health'WASHINGTON, Oct. 18 — The House on Thursday upheld President Bush’s veto of a bill to provide health insurance to 10 million children , but Democrats vowed to send it back to him next month, with minor changes, in the belief that they could ultimately prevail.' Roll call graphic
''I mean, people have access to health care in America,'' said Mr. Bush in July. ''After all, you just go to an emergency room.''
On a related note in today's NY times:Neanderthals May Have Had Gene for Speech:)
Just an interesting tidbit I saw in the paper today 10/25/07From Harvard Dropout to Instant Billionaire
Four years ago Mark Zuckerberg was just another geeky psychology student at Harvard - now he's a paper billionaire who's often compared to Bill Gates and Steve Jobs.
With his brainchild, Facebook, now valued at $US15 billion ($16.8 billion) after Microsoft purchased a 1.6 per cent stake in the social networking site for $US240 million, the 23-year-old has turned his dorm room hobby into a star of the second web boom.
With a 20 % stake in the company, Zuckerberg could theoretically sell out now and walk away with a cool $US3 billion.
In an interview with Forbes magazine last year, Zuckerberg said Bill Gates, also a Harvard dropout, inspired him to skip school to work on outside projects during a talk Gates gave to one of his computer science classes in 2004.
"He really encouraged all of us to take time off school to work on a project. That's a policy at Harvard - you can take as much time off as you want," Zuckerberg said
OK..NOT the policy at IUPUI. We're far too busy to be creative billionaires. Now get back to work, you.
11/6/07: Election Results: New Jersey Voters Defeat Stem Cell MeasureIn a stunning defeat for Gov. Jon S. Corzine, New Jersey voters rejected a ballot measure to permit the state to borrow $450 million for stem cell research.
11/5/07: J. Craig Venter interview on NPR's Fresh Air with Terri GrossA Life Decoded, and more!!
10/31/2007: Cinnamon the cat - a 4-year-old Abyssinian The Kitty Genome!
"Geneticists have turned up 20,285 genes, the analysis of which could shed light on everything from human diseases to the underpinnings of feline domestication."
"Initial sequence and comparative analysis of the cat genome". Genome Res.17: 1675-1689
NIH, Broad Institute, etc
"2x genomes—Does depth matter?"Genome Res17:1547-1549, 2007
"Once the superiority of the shotgun approach was accepted..."
11/15/07: Stem Cell News: Scientists Use Monkey Clones to Extract Stem Cellsok I lied.. the original Monkey's name was Semos...More inNature;Paper in advance of print
11/15/07: Stock news: Starbucks Shares Plunge on Drop in Customer VisitsHigher cost of milk, competition from McDonald's coffees...is nothing sacred?
News of the day:
11/27/07: Exam questions in the news!
Round 2 for Biotech Beets11/27/07 Sugar industry ready to accept RR beets!
Scotts to pay $500,000 fine over Biotech Bentgrass11/26/07 Ouch! Largest civil penalty APHIS can demand.
Proposed Ban on Genetically Modified Corn in Europe11/23/07 Precautionary principle revisited
Adventurer in Genome Science 11/23/07 New book review of You Know Who
World at a cloning crossroads, U.N. study says11/11/07
...and the 2 Big Ones: 11/21/07: Stem Cell News! New Stem Cell Method Could Ease Ethical ConcernsTwo teams (Shinya Yamanaka et al. and James Thompson et al.) report refinements to the iPS story...with HUMAN cells!
[PDF - Yamanaka, Cell][PDF - Thompson, Science](in advance of print)
My vote for "THE" scientific news of 2007!
NEW: Extra Credit Assignment: Read the Thompson Paper... See Oncourse for more details