mAB Drugs
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Surfing Biotech's Second Wave: Monoclonal Antibody drugs
September 15, 2009

 

Homework Note: The notes below are AGAIN in OUTLINE form and require you to do a bit of homework (~2 hours of time before class). For each drug listed below, go to the link provided and read about the drug to determine:
(1) The Target: what human protein is recognized by the mAb?
(2) Indication: why the mAb is prescribed and what it does it do in the body?

Monoclonal antibodies: be sure you are familiar with these terms and procedures:

A question before we begin: What do all these words have in common?
* Alemtuzumab
* Gemtuzumab ozogamicin
* Rituximab
* Trastuzumab
* Ibritumomab tioxetan

 

Answers (circle all that apply):

  1. They are all relaxation chants used in Hatha Yoga
  2. They all sound like "Number 9, Number 9" if you pronounce them backwards
  3. They are all code words for admission to a secret society of M.D.s
  4. They all end in -mab, shorthand for monoclonal antibody
  5. They are all names of monoclonal antibody based drugs targeted to cancer cells!
If you guessed 4 and 5 = you're right!

Major Competitors in the Transplantation Antibody Therapy Market:

 
Target: what human protein recognized by the mAb
Indication: why the mAb is prescribed and what it does in the body
Other notes
1. Orthoclone OKT3
(Muromonab) 
      
2. Simulect
(Basiliximab)
      
3. Zenapax
(Daclizumab)
      
Major Competitors in the Oncology Market:

 
Target: what human protein recognized by the mAb
Indication: why the mAb is prescribed and what it does in the body
Other notes
1: Rituxan
(Rituximab)
      
2: Zevalin
(Ibritumomab)
     
3: Bexxar
(Tositumomab)
     
4: Herceptin
(Trastuzumab)
      
5: Avastin
(Bevacizumab)
      
6: Erbitux
(Cetuximab)		      
7: Campath
(Alemtuzumab)
      
8: Mylotarg
(Gemtuzumab) 		     

 

Q: What is WAY cool about Zevalin and Mylotarg? You tell me!

Major competitors in the T-cell autoimmune disease market:

 
Target: what human protein recognized by the mAb
Indication: why the mAb is prescribed and what it does in the body
Other notes
1: Enbrel *
(Etanercept)
      
2: Amevive *
(Alefacept)
     
3: Remicade
(Infliximab)
     
4: Humira:
(Adalimumab)
      
5: Raptiva
(Efalizumab)
     

Misc. mAb Drugs

 
Target: what human protein recognized by the mAb
Indication: why the mAb is prescribed and what it does in the body
Other notes
1. Synagis
(Palivizumab)
      
2. ReoPro
(Abciximab)
      
3. Xolair
(Omalizumab)
     
4. Lucentis
(Ranibzumab)
      

OBJECTIVES:

 

1. When making monoclonal antibodies, what is the purpose of: the immunized mouse (and its poor spleen)? What are myeloma cells and why are they so useful in this technique? What is a hybridoma? How are experimental conditions set up to select for hybridomas?

2 . What is meant by the terms chimaeric monoclonal antibody and humanized monoclonal antibody?

3. For each drug listed below, be sure to know: (1) the target antigen, (2) the indication, (3) what the mAb does in the body.

 

Transplantation: Orthoclone OKT3, Simulect , Zenapax
 Oncology: Rituxan, Zevalin, Bexxar, Herceptin, Avastin, Erbitux, Campath, Mylotarg
T-cell autoimmune: Enbrel, Remicade, Humira, Amevive, Raptiva   
Misc: Synagis, ReoPro, Xolair, Lucentis

 

Do you have to know the mysterious 'xyz'-mab names? Not for me, but you MAY need to know all of these someday soon!

 

...........................................................Copyright Kathleen A. Marrs 2007