mAB Drugs

 

A Few Mechanism of actions (MOAs)

Major Competitors in the Transplantation Antibody Therapy Market:

Orthoclone OKT3, (after and before humanization)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Major Competitors in the Oncology Market:

Rituxan, Zevalin, Bexxar,

 

Herceptin, Erbitux,

 

Avastin, Lucentis

 

 

Mylotarg

 

 

Major Competitors in the T-Cell Autoimmune Disease Market:

Enbrel, Remicade,  Humira, Amevive, Raptiva 

Enbrel is a fusion ptn IgG+TNF receptor,
Remicade and Humira are mAbs to TNF (Remicade is 'fully human')

Amevive (fusion ptn) and Raptiva (mAb) suppress different T-lymphocytes

 

Misc:

ReoPro

Xolair

 

 

Drug Overdose II:

Categorize YOUR fave mab drugs:

 

Angiogenesis Inhibitors	Depletion of B-cells
HER Signalling	Immunosuppressive Therapy