Up 11 is due Wednesday April 7, 2004, at 9:30 am
at the lecture notes and do the readings before (or while) doing the Warm
Up. You may need to look terms up in the book's glossary or on the CD (or
First name :
Last name :
Class Section (1, 2 or 3):
(See Oncourse to determine whether you are in 1= A410, 2 = A411, or 3 = A413)
Please enter a nickname (in case your answer is used in
The following three questions refer to material
you were to read in preparation for class. These questions require you to
write a three or four sentence response. It is OK to answer 'I don't know'
- but STATE WHY you are confused! (Don't just say 'I don't know' - you probably
DO!) Each WarmUp worth 3 points if answered on time and must be submitted
via the web. See notes page for prior Warm Ups and student responses.
QUESTION 1: Achondroplasia
is a dominant genetic disorder and causes severe changes in skeletal and bone
growth and development, resulting in a dwarf phenotype. People who are not
dwarfs - this includes most or all N100 students - are homozygous recessive
for this gene (aa). People with achondroplasia (dwarfism) are all heterozygous
(Aa). However, no people with dwarfism are homozygous
dominant for this trait (There are no people who have the genotype
AA). Why do you think the genotype AA is not
found is people with dwarfism?
From libo: q1: The genotype AA is not found because If
they have AA it is lethal. That means that they will not be
alive to find it. THis is because AA results in spontaneous abortion of the
From meg: q1: it is lethal- fatal (spontanious
abortion of fetus) anyone who would have AA dies in the womb
From ja: q1: Dwarfism is a disease that affects the growth
of the body and limbs. If a fetus has the AA genotype it would affect the
growth of limbs and body so much that the fetus
would not survive.
QUESTION 2: Allison is driving with her parents, Kate and Bob, when
they get in a serious car accident. At the emergency room, her doctor (you)
tells Allison that her mother is fine, but her father has lost a lot of blood
and will need a blood transfusion. Allison volunteers to donate blood, and
you tell her that her blood type is AB. Bob is type O. (1) Can Allison donate
blood to Bob? Why or why not? (2) Allison, who is a biology student, begins
to wonder if she is adopted. What would you tell her and why?
From 'mos: q2: I am not sure about donating blood, but
i would guess that it is not possible for a
AB doner to donate to an 0 pacient because there is no genetic
simularity between the two types. That being the case i would also think that
Allison is indead adopted. Her AB blood
reqires IaIb genotype and contains no resesive i allels. If bob was indead
her father he would have contributed one resesive i allel to her genotype.
From babes: I not real sure but I think that she
would not be able to give blood to her father but he could
give blood to her because he is type O and has the recessive gene of AB. She
is probably right that she is not related because
her father only carries ii and she received Ia Ib.
From Shifty-eyed Swindler: 1. No she can not. Her father
can only receive type O blood,
since his body would treat any other blood type as 'foreign'. 2. Bob
can not be her father. Her father's genotype is ii, so, depending on
her mother's blood type, Allison should be either IA i (type A) or IB (type
Sex linked disorders (carried on the X chromosome) like
color blindness, hemophilia, and muscular dystrophy, are frequently passed
from carrier mothers to sons, who are affected with the disorder because they
have only one X chromosome. However, sometimes females
are born with color blindness, hemophilia, or muscular dystrophy. How
can this happen?
From Daisy Mae: q3: Daughters can only have these x-linked
genetic diseases if her mom carries the disease
and her father expresses (is afflicted) with it. A good number
of x-linked diseases are not passed on because they are deadly to a father
who may or may not make it to an age where he can reproduce.
From susie: q3: This can happen if the mother's
are carriers of the diseases and if the male has one of the diseases
because in order for a girl to inherit one of the diseases there has to be
two recessive alleles.
From ed: q3: It happens when mom
is a carrier and if dad is color blind
From ardre: q3: If they inherit
the allele from both parents, it will be expressed.
This is rare; the girls will in most cases be a carrier.
q4: It is crazy how things work and how each one of us are
created and how each one of us is quite different all because of genetics.
q4: It makes my head hurt to think about it.
q4: I find this confusing and understanding the logic that
determains the charastic that we are liiking and relating the Homo..../hetro...
aspects of my chart results. I will keep working on it...
q4: This stuff is interesting but really confusing!!!! I
hope will talk more about the second and third questions in this warm up in
class Wednesday. I really had a hard time figuring out the answer.
q4: This is very interesting. You need to keep up with notes
and lectures or you will be left behind. This is not a subject you could sit
down at home and figure out on your own, not for me anyway.
q4: Is there any trick or memory device to remembering which
autosomal disorders are dominant, recessive, or related to the sex chromosomes?
q4: I am a camp counselor at the muscular dystrophy camp
every summer, and I see lots of children with this genetic disorder. It is
amazing that there are so many different types of muscular dystrophy. And
I have noticed that there are more males than females there. Interestingly
enough, two of the girls in my cabin are identical twin girls who have a severe
form of muscular dystrophy. I guess I never thought of genetic disorders and
how they affect twins.
q4: I think the material we have been covering is very interesting.
I find this stuff more useful to me in everyday life.