The focus of my research is to investigate the cellular and molecular mechanisms through which nutrients affect human health. I, particularly, investigate how trans fatty acids (found in hydrogenated oils) and omega-3 fatty acids (found in fish oil) influence the development and progression of cardiovascular diseases and cancer. Our cellular and animal models have shown that trans-fatty acids instigate molecular processes that induce atherosclerosis and sudden cardiac death whereas omega-3 fatty acids provide protection against cardiovascular diseases. At present, we are investigating effects of dietary fatty acids on endothelial cell function and vascular remodeling. My laboratory is also investigating the synergistic properties of omega-3 fatty acids with other nutrients, particularly polyphenols (found in fruits and vegetables), for their beneficial cardio-protective and anti-cancer properties. One other aspect of my research is to investigate processes that lead to muscle wasting (cachexia) in chronic diseases, particularly in cancer patients. We also investigate how nutritional compounds prevent muscle wasting and improve quality of life in cancer patients.
Department of Biology