IUPUI Department of Biology
723 W Michigan Street,
Indianapolis, IN 46202
phone 317 278 5717
Fax: 317 274 2846
Dr anna malkova phd
Department of Biology
Dr. Anna Malkova, Ph.D
My research interest is in DNA repair, recombination and replication. I conduct my studies using baking yeast as a model organism.
I received my Ph.D in Genetics in 1993 from the Department of Genetics, St.Petersburg State University, Russia. I came to the United States in 1993 and spent nearly a decade as a post-doctoral fellow at Brandeis University in the laboratory of Dr. James Haber. During that time we identified Break-Induced Replication (BIR), an alternative form of DNA synthesis initiated by double-strand DNA break..
Today my research at IUPUI focuses on BIR. It has been suggested that some mammalian tumor cells use BIR to stabilize their chromosomal ends, leading to immortalization. BIR is implicated in formation of chromosomal rearrangements that affect genes involved in cell cycle regulation, leading to cancer. This is why it is very important to understand how BIR is carried out and regulated.. Additionally, I am interested in effect of inverted DNA repeats (and various other “at-risk” DNA motifs) on DNA repair. Thus, we investigate how inverted DNA repeats mis-rout double-strand break repair into pathways that result in gross chromosomal rearrangements (GCRs). Studying pathways that lead to GCRs is important because it will unravel the underlying cause of chromosomal aberrations that may be the mechanism of formation for different types of cancer.
Education and Training
Ph.D./1993 St. Petersburg State University, St. Petersburg, Russia, Genetics.
B.S./1987 St. Petersburg State University, St. Petersburg, Russia, Genetics.
1997-2003 Brandeis University, Waltham, MA. (Mentor: J.E. Haber).
1993-1996 Brandeis University, Waltham, MA. (Mentor: J.E. Haber).
2009-present Associate Professor, Department of Biology, Indiana University-Purdue University Indianapolis.
2003- 2009 Assistant Professor, Department of Biology, Indiana University-Purdue University Indianapolis.
2004-present Adjunct Assistant Professor, Department of Medical and Molecular Genetics, Indiana University School of Medicine.
Research Associate, Brandeis University, Waltham, MA.
1997-2000 Postdoctoral Fellow, Brandeis University, Waltham, MA.
1996-1997 Staff Scientist, St. Petersburg State University, St. Petersburg, Russia.
1993-1996 Postdoctoral Fellow, Brandeis University, Waltham, MA.
1987-1993 Graduate student, St. Petersburg State University, St. Petersburg, Russia.
Honors and Awards
2009 Outstanding Leadership and Mentoring of Undergraduate Research IUPUI Center for Research and Learning Award.
2010 School of Science Research Award