IUPUI Department of Biology

723 W Michigan Street,

Indianapolis, IN 46202

phone 317 278 5717

Fax: 317 274 2846

Dr anna malkova phd

Email:amalkova@iupui.edu

Department of Biology

Dr. Anna Malkova, Ph.D

Contact Info

E-mail: amalkova@iupui.edu

Phone: 317-278-5717

Research Interests

My research interest is in DNA repair, recombination and replication.  I conduct my studies using baking yeast as a model organism.

 I received my Ph.D in Genetics in 1993 from the Department of Genetics, St.Petersburg State University, Russia.  I came to the United States in 1993 and spent nearly a decade as a post-doctoral fellow at Brandeis University in the laboratory of Dr. James Haber.  During that time we identified Break-Induced Replication (BIR), an alternative form of DNA synthesis initiated by double-strand DNA break.. 

Today my research at IUPUI focuses on BIR.  It has been suggested that some mammalian tumor cells use BIR to stabilize their chromosomal ends, leading to immortalization. BIR is implicated in formation of chromosomal rearrangements that affect genes involved in cell cycle regulation, leading to cancer.  This is why it is very important to understand how BIR is carried out and regulated..  Additionally, I am interested in effect of inverted DNA repeats (and various  other “at-risk” DNA motifs) on DNA repair.  Thus, we investigate how inverted DNA repeats mis-rout double-strand break repair into pathways that result in gross chromosomal rearrangements (GCRs).   Studying pathways that lead to GCRs is important because it will unravel the underlying cause of chromosomal aberrations that may be the mechanism of formation for different types of cancer. 

Education and Training

Ph.D./1993                     St. Petersburg State University, St. Petersburg, Russia, Genetics.

B.S./1987                       St. Petersburg State University, St. Petersburg, Russia, Genetics.

Postdoctoral Training:

1997-2003                     Brandeis University, Waltham, MA. (Mentor: J.E. Haber).

1993-1996                     Brandeis University, Waltham, MA. (Mentor: J.E. Haber).

 

Academic Appointments

2009-present                  Associate Professor, Department of Biology, Indiana University-Purdue University Indianapolis.

 

2003- 2009                    Assistant Professor, Department of Biology, Indiana University-Purdue University Indianapolis.

2004-present                  Adjunct Assistant Professor, Department of Medical and Molecular Genetics, Indiana University School of Medicine.

Research Associate, Brandeis University, Waltham, MA.

1997-2000                      Postdoctoral Fellow, Brandeis University, Waltham, MA.

1996-1997                     Staff Scientist, St. Petersburg State University, St. Petersburg, Russia.

1993-1996                      Postdoctoral Fellow, Brandeis University, Waltham, MA.

1987-1993                     Graduate student, St. Petersburg State University, St. Petersburg, Russia.

Honors and Awards

2009                               Outstanding Leadership and Mentoring of Undergraduate Research IUPUI    Center for Research and Learning Award.

2010                               School of Science Research Award