Biol 540 Schedule
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Schedule for Biotechnology 540, Fall 2007:
Note: Subject to change as we finalize guest speaker dates and topics!



What is Biotechnology?

First Night questions


Biotechnology Timeline 2007; Outline version for class
Questions - Cohen and Boyer; Answers


Surfing the First Wave: Recombinant DNA drugs (Homework!)
Drug case studies; Answers


Surfing the First Wave: Recombinant DNA drugs (Full notes)

Evil Warm Up 1 - responses


Biotech's Second Wave: Monoclonal Antibody-based Drugs (MORE drugs!)
Biotech's Second Wave: Monoclonal Antibody-based Drugs (Full notes); and MOAs


Investing in Biotechnology ; Investing (Full notes and Lots of Advice )
Biotech Stock Project (slightly revised from the one handed out in class!)


Finish Investing
Biotech Team Project


Getting a Drug to Market: Clinical Trials - *Michael Turik, MD, The Lilly Laboratory for Clinical Research - NOTE: Background reading!


Alza Drug Delivery
Finish up Clinical Trials


Post Modern Science - Joe Petolino, PhD
Discovery R&D Scientist, Dow AgroSciences.


The Cloning of Dolly and Other Mammals
Cloning Questions


Human Embryonic Stem Cells, Part I
Embryo Donation: Informed Consent - Adoption or Embryonic Stem Cells
Human Embryonic Stem Cells, Part I (Full Notes)



Exam 1 Study Guide: All the objecives on 1 page!

10/9/07 Gene Therapy - Ken Cornetta MD [web], Chair, Department of Medical and Molecular Genetics, IUSM; Director, Indiana University Gene Vector Facility
10/11/07 Adult and Pleuripotent Stem Cells - Merv Yoder, MD, Department of Pediatrics, IUSM; Biochemistry and Molecular Biology. Please read BEFORE Dr. Yoder's lecture!

Therapeutic Cloning and Politics ...Full notes
Plus - check up on Stock Project, Team Project, and Exam I!


Therapeutic Cloning and Politics ...Full notes (Finish!)



Human Genome Project I...*Full notes (re-posted Tuesday 9 pm)*



Human Genome Project II...Full Notes on J. Craig Venter


10/30/07 Nutrigenomics - Starting a Nutritional Genetic Company: Manuel Sanchez-Feliz, PhD, Chief Technical Officer, Sciona; Research Advisor, Eli Lilly

Ag Biotech I: Joe Petolino, PhD Discovery R&D Scientist, Dow AgroSciences
Readings; Full notes from Dr. Marrs


Ag Biotech II: Who's who in Ag Biotech; Products on the Market; ... Full notes

And... Gene Patents (From Dr. Marrs - NOT a patent attorney)


Patents and Intellectual Property - Lynn Tyler, Attorney and Partner, Barnes and Thornburg [Bio]


Ag Biotech III: Environmental regulation - US and International


Ag Biotech IV: Safety of GM crops and food


Exam 2



No Class - Thanksgiving Break



Biotechnology and Global Health, ... Full Notes,
Here is some background on MicroRNAs...we will not have a chance to get to this!


Team Projects 1-5; Link to projects



Team Projects 6-10



Team Projects 11-15



FINAL EXAM (Cumulative) Tuesday, 6-8 pm
NEW: Final Exam Objectives - All on ONE PAGE!


Previously on the Right sidebar... (for historical reference)

Tip of the Day 8/30/07

IGNORE Oncourse for now, uness you have a Blunt Object you can use to BEAT IT mercilessly.

Instead, think about sailing peacefully on the Sorcerer II, circumnavigating the globe... not uploading anything to Oncourse... we'll just pause on the Warm Up assignment for now...stay tuned!


NY Times 4 Sept 07 In the Genome Race, the Sequel Is Personal Craig Venter's genome revealed...take a look!

Check out the manuscript in PLoS Biology! The Diploid Genome Sequence of an Individual Human"We have generated an independently assembled diploid human genomic DNA sequence from both chromosomes of a single individual (J. Craig Venter)..."

But Craig wasn't the first!
NY Times 31 May 2007 Genome of DNA Pioneer Is Deciphered ie: James Watson, courtesy of 454 Life Sciences!


PS. "His Master's Voice" Early ad for RCA victor (compare to the Dog Genome cover)


Investor excitement: ImClone Claims Positive Erbitux Results on Lung Cancer:A.P. NEW YORK -9/11/07
By DAMIAN J. TROISE 09.11.07, 5:49 PM ET

ImClone Systems Inc. and Bristol-Myers Squibb Co. claimed Tuesday that the drug Erbitux improved the survival rate of patients with the most common type of lung cancer in a late-stage study. Shares of ImClone climbed $6.97, or 18 percent, to $44.90 Tuesday. The stock reached a 52-week high of $47.22 earlier in the trading session.

Thanks to Joey F. from class for sending this in! ...................

NY TImes 9/7/07 Two Biotech Companies Agree to Form a Joint Venture Alnylam Pharmaceuticals and Isis Pharmaceuticals - joint venture to develop Regulus Therapeutics,an miRNA company - More on this later! [What do you think about the company name?!]

Thanks to Natalie P. from class for sending this in!


Wal-Mart Adds Drugs to $4 Program

Wal-Mart is expanding its $4-a-month generic drug program, adding about seven new compounds

The company said it would also sell a month’s supply of two popular birth control medications and a fertility drug for $9 each, a move meant to lure young women shoppers to the store.

The company said it decided to offer those drugs at $9 because they would not have been profitable at $4.


News of the day:

Bush Vetoes Popular Bill on Kids' Health CareWASHINGTON Oct 3 - Well, no surprise here! This is only veto #4 of his presidency...2 on stem cells, one on S-chip...

Senate Passes Children’s Health Plan WASHINGTON, Sept. 27 — The Senate gave final approval on Thursday to a health insurance bill for 10 million children, clearing the measure for President Bush, who said he would veto it.

The 67-29 vote followed a series of speeches by Republican senators supporting the bill and urging Mr. Bush to reconsider his veto threat.

Senator Pat Roberts of Kansas, one of 18 Republicans who voted for the bill, said the White House had shown “little if any willingness to come to the negotiating table.”


3 Win Nobel in Medicine for Gene ManipulationOctober 8, 2007 7:52 a.m. ET STOCKHOLM, Sweden (AP) --'U.S. citizens Mario R. Capecchi and Oliver Smithies and Sir Martin J. Evans of Britain won the 2007 Nobel Prize in medicine on Monday for groundbreaking discoveries on gene targeting, which lets scientists inactivate or modify particular genes in mouse embryonic stem cells. That in turn lets them study how those genes affect health and disease'.

Physics of Hard Drives Wins NobelOctober 9, 2007 1:56 pm. ET STOCKHOLM, Sweden (AP) --
'France's Albert Fert and German Peter Gruenberg for giant magnetoresistance' = the magnetic hard drive that runs your iPod, MP3 player, etc!

Each prize awards $1.5 million to share between the recipients!


House Sustains President’s Veto on Child Health'WASHINGTON, Oct. 18 — The House on Thursday upheld President Bush’s veto of a bill to provide health insurance to 10 million children , but Democrats vowed to send it back to him next month, with minor changes, in the belief that they could ultimately prevail.' Roll call graphic

''I mean, people have access to health care in America,'' said Mr. Bush in July. ''After all, you just go to an emergency room.''

On a related note in today's NY times:Neanderthals May Have Had Gene for Speech:)


Just an interesting tidbit I saw in the paper today 10/25/07From Harvard Dropout to Instant Billionaire

Four years ago Mark Zuckerberg was just another geeky psychology student at Harvard - now he's a paper billionaire who's often compared to Bill Gates and Steve Jobs.

With his brainchild, Facebook, now valued at $US15 billion ($16.8 billion) after Microsoft purchased a 1.6 per cent stake in the social networking site for $US240 million, the 23-year-old has turned his dorm room hobby into a star of the second web boom.

With a 20 % stake in the company, Zuckerberg could theoretically sell out now and walk away with a cool $US3 billion.

In an interview with Forbes magazine last year, Zuckerberg said Bill Gates, also a Harvard dropout, inspired him to skip school to work on outside projects during a talk Gates gave to one of his computer science classes in 2004.

"He really encouraged all of us to take time off school to work on a project. That's a policy at Harvard - you can take as much time off as you want," Zuckerberg said

OK..NOT the policy at IUPUI. We're far too busy to be creative billionaires. Now get back to work, you.



11/6/07: Election Results: New Jersey Voters Defeat Stem Cell MeasureIn a stunning defeat for Gov. Jon S. Corzine, New Jersey voters rejected a ballot measure to permit the state to borrow $450 million for stem cell research.

11/5/07: J. Craig Venter interview on NPR's Fresh Air with Terri GrossA Life Decoded, and more!!

10/31/2007: Cinnamon the cat - a 4-year-old Abyssinian The Kitty Genome!

"Geneticists have turned up 20,285 genes, the analysis of which could shed light on everything from human diseases to the underpinnings of feline domestication."

"Initial sequence and comparative analysis of the cat genome". Genome Res.17: 1675-1689
NIH, Broad Institute, etc

Related article:
"2x genomes—Does depth matter?"Genome Res17:1547-1549, 2007
"Once the superiority of the shotgun approach was accepted..."


11/15/07: Stem Cell News: Scientists Use Monkey Clones to Extract Stem Cellsok I lied.. the original Monkey's name was Semos...More inNature;Paper in advance of print

11/15/07: Stock news: Starbucks Shares Plunge on Drop in Customer VisitsHigher cost of milk, competition from McDonald's nothing sacred?